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From a clinical perspective, the stress-induced up-regulating effect on the afore-mentioned CYPs could result in acceleration of the metabolism of their drug-substrates and therefore, in sub-therapeutic drug levels in blood and tissues ( There is also an indirect involvement of stress in drug metabolism as long-term exposure to uncontrolled stress may trigger several pathophysiological states including cancer, depression, inflammatory diseases, diabetes mellitus and other diseases within the spectrum of metabolic syndrome, which comprise modified hormonal, nutritional, immune and psychological states compared to healthy population ( Age-related modifications of critical parameters determining hepatic drug metabolism Although a comprehensive definition of ageing is not possible, several characteristic alterations including the time-related loss of functional units of organs, the disruption of functional integration between cells and organs and the failure in preserving homeostasis under stress are recognized