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This resulted in elevated activity of Caspase-3 and Caspase-9, increased expression of the pro-apoptotic protein Bax, decreased expression of the anti-apoptotic protein Bcl-2, and ultimately promoted apoptosis in PASMCs

The EMG examination revealed a reduction in compound muscle action potentials (CMAP), suggesting chronic neurogenic damage without signs of active denervation

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Statistical analysis Experiments were independently repeated at least two times with differing biological samples, with similar results