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Pathway dysregulation has been observed in the brain, urine and plasma of PD patients, showing a significant reduction of antioxidant enzyme activity along with an increased level of oxidative stress (Kovac et al., 2015), the loss of dopaminergic neurons in association with microglia activation (Rojo et al., 2010) and exacerbation of synuclein aggregation (Lastres-Becker et al., 2012)

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