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Gene structure and expression regulation Human APOA1/C3/A4/A5 gene clusters are located on chromosome 11q23, where APOC3 gene is approximately 35 kbp upstream from the APOA5 gene locus [9]

Effect of polygonum cuspidatum and hawthorn on anti-atherosclerosis unstable plaque

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Liposomes encapsulating siRNA against the HIV gag gene demonstrated potent antiviral activity even in drug-resistant viral strains

Thalidomide therapy and polyneuropathy in myeloma patients

reported that HIF-1 can regulate the malignant progression of GBM under hypoxic conditions and that hyperbaric oxygen significantly inhibits HIF-1 expression, increasing the sensitivity of GBM cells to chemotherapy ( TGF-1 induces HIF-1 overexpression and nuclear accumulation by upregulating NOX4 expression and ROS production, ultimately leading to metabolic reprogramming and promoting EMT