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379 In PGC-1 knockout mouse models, DA neurons exhibit increased sensitivity to the neurotoxin MPTP, potentially due to the lack of PGC-1-mediated induction of antioxidant responses

Another reaction that generates free radicals is the purine metabolism, where xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and subsequently to uric acid, and during its re-oxidation, molecular oxygen is reduced to superoxide [31]

Up to 40 per cent of older people in the UK suffer from low B12 levels because of impaired absorption and as most meat is consumed after cooking, there are further losses of B12

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Bonus- they're also crucial for the regulation of neurotransmitters like serotonin and dopamine, to help lower stress and anxiousness

they made an impact on searching vitamin B 12 deficiency in MS and presumed aggravation of MS or impair recovery in B 12 deficiency.[15] Njist et al .[14] reported that B 12 concentrations in CSF (measured with a radioimmunoassay) and serum of MS patients were lower in control subjects