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10.1016/j.jacc.2013.05.019 108 YangW

doi: 10.1007/s00125-020-05333-y 65 MishraMKowluruRA

This is hyperplasia, not just hypertrophy

Studies in animals and brain imaging in humans support the idea that similar brain circuits are affected in obesity and drug dependence, and dopamine-modulated reward circuits play a role in abnormal eating behaviors

In aged rodents, spermidine (SPD) or spermine (SPM) increased median and maximal lifespan by 1018% and reduced mortality by up to 35%, while maintaining cardiac, metabolic, hepatic, and neuronal functions [103,104]

Both, the alpha-class related gst-32 and the GPX are implicated in the oxidative stress response by way of their GSH-dependent reduction of inorganic and organic peroxides or by their ability to eliminate secondary products of lipid peroxidation