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Statements Author contributions PL: Data curation, Investigation, Methodology, Writing original draft

By targeting the Nrf2 signaling pathway with compounds, such as osthole, 5-hydroxymethyl-2-furfural (5-HMF), and paeonol, researchers have effectively reduced oxidative damage and BBB permeability in mouse models of ischemia (Zhao et al., 2014

Their effectiveness gets a significant boost when combined with glutathione

British Journal of Dermatology , 142 (1), 44-51

DNA replication in eukaryotic cells

While these provide valuable mechanistic insights, additional in vivo studies are required to confirm the effects of FM19G11-loaded NPs on epSPC energy metabolism and, crucially, to demonstrate their capacity to promote neurogenesis