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Use a drilling machine to remove 90% of the material

Res 35 , 17491758 (2011)

After an interim analysis, mAb114 monotherapy and REGN-EB3 were both found to be superior to ZMapp with respect to the primary outcome and patient mortality 179 , and were approved by the FDA for the treatment of EVD in 2020 (refs 180,181 )

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Production of GSH occurs by two mechanisms, de novo synthesis and recycling of GSSG

But the leaks (oxidative stress, inflammation, mitochondrial injury) usually start years earlier