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Interestingly, in the context of the transgenic mice expressing the mutant human B-crystallin, heterozygous knockout of Nrf2 lessened reductive stress decreasing the expression of the enzymes involved in GSH biosynthesis and recycling, resulting in a decrease in GSH concentration and the GSH/GSSG ratio

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B cell lymphoma), calcitriol has been shown to suppress the proliferation of immune cells and production of IFN-, thereby altering the efficacy of rituximab (therapeutic antibody)-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) on effector -T cells along with enhancing the cytotoxic effects of effector NK cells in vitro [185]

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2.3 Univariable and multivariable regression analysis Adverse event data from eight ICIsnivolumab, pembrolizumab, cemiplimab, toripalimab, tislelizumab, atezolizumab, durvalumab, and avelumabwere pooled for regression analyses, with respiratory adverse events defined by PTs as the outcome of interest

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W.FraunfelderF

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Virus has been reported in brain endothelium or olfactory epithelium/mucosa in infected human subjects and non-human primates (NHPs), however, this does not extend to cells residing within the brain parenchyma (Meinhardt et al., 2021

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