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First, only two out of the four studies considered vitamin B 12 , methylmalonic acid and homocysteine levels as possible confounders for the response to vitamin B 12 therapy.(10,11) Vitamin B 12 deficiency is known to cause peripheral neuropathy and is a risk factor for development of DPN in diabetics who are on metformin

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Intagliata S, Salerno L, Ciaffaglione V, Leonardi C, Fallica AN, Carota G, et al

In summary, here whilst Hph-1 animals showed the expected correlation between BH 4 and NO, this did not lead to an increase in ischaemia-induced neural cell apoptosis

This study is a clinical demonstration that the liver is the key organ in haemochromatosis, not only as a target of iron overload but also as the cause of iron excess through hepcidin deficiency

To trap these evanescent species, we rapidly isolated and snap-froze a panel of mouse and rat tissues (Fig