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In the prodromal and early stages of Alzheimer's disease, researchers have documented significant changes in fatty acid composition within lipid rafts, along with a marked increase in cerebral lipid peroxidation (70)

Hooper NM, Watt NT, Whitehouse IJ (2011) The role of zinc in Alzheimers disease

Notably, these pathological alternations and reductive stress were significantly normalized by replacing the wild-type G6PD with a hypomorphic G6PD mutant in the R120G mice (77), suggesting that the G6PD-mediated reductive stress contributes to the development of this disease

Direksunthorn T, A TA, Pluetrattanabha N, Uthirapathy S, Ballal S, Singh A, Al-Hetty H, Devi A, Sharma GC, Yumashev A

Nature (2010) 465:2437

B., Ryan, A