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Yokota N, Burne-Taney M, Racusen L, Rabb H

Systematic review and meta-analysis: clinical, endoscopic, histological and safety placebo rates in induction and maintenance trials of ulcerative colitis

PMCID: PMC3821496 Garca-Senz M, Lobaton-Ginsberg M, Ferreira-Hermosillo A

As the intimal volume enlarges due to accumulating cells, there is vascular remodeling to lessen protrusion of the lesion into the lumen (Figure 4), thereby decreasing occlusion and the appearance of clinical symptoms for much of the life of the lesion (165-167)