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Berberine Attenuates Calyculin A-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells

doi: 10.3390/cancers15143731 57 FriedmannAngeli JPSchneiderMPronethBTyurinaYYTyurinVAHammondVJet al

Nonmodifiable Risk Factors Age constitutes the most wellestablished nonmodifiable risk factor for PD, with multifaceted cellular aging processes fundamentally contributing to dopaminergic neuron vulnerability

Such ulcers significantly reduce patients quality of life, escalating healthcare costs, and can lead to severe outcomes such as infections, amputations (Schwarz et al., 2013), and even death (Senneville et al., 2024)