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A randomized controlled trial conducted in 2023 revealed that selenium supplementation significantly decreased TPO-Ab, TSH, and MDA levels in patients with HT, indicating improvements in both thyroid autoimmunity and oxidative stress markers (Negro et al

For example, the expression of ALOX15 is mediated by spermidine/spermine N1-acetyltransferase 1, a tumor protein p53 (TP53) target gene, and is involved in TP53-mediated ferroptosis (Ou et al., 2016)

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J Biol Chem 179:12451254 Buonocore D, Grosini M, Giardina S, Michelotti A, Carrabetta M, Seneci A, Verri M, Dossena M, Marzatico F (2016) Bioavailability study of an innovative orobuccal formulation of glutathione

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