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Data extraction Data extraction was conducted in duplicates and independently, using a standardized form to capture animal model details (species, strain, ASD model, sex, age), intervention type (dosage, route, frequency, duration), outcome measures (behavioral assessments, gene expression, neurotransmitters, immune signaling, hormonal measures, gut microbiota composition), and study limitations or any observed adverse effects on the animals

Hypermethylation is an epigenetic event thus is common in patients with sporadic EC

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