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Obesity is not a one-size-fits-all issue

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The pathogenic role of copper is context-dependent and exhibits a U-shaped risk curve

In this review, we have discussed the potential mechanisms of renal tubular injury in DKD, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death

Kanwar N, Hu P, Bedard P, Clemons M, McCready D, Done SJ

Overall, these results showed that inhibition of anti-ferroptosis mechanisms enhanced the anti-leukemic activity of APR-246 in vivo