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Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

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Haematological response typically occurs within one week, whilst neurological symptoms may take several months to improve and recovery may be incomplete if treatment was delayed

This fact, linked to the augmented FFA use by muscle and insulin signal reinstitution by IGF-1, results in a marked reduction in total FFA flux

However, for patients who want nutritional metabolic support especially those with identified deficiencies in choline or B vitamins they may provide a reasonable complement to evidence-based weight management strategies