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Patients with CS pruritus had significantly higher (worse) scores on all PBC-40 domains than those with non-CS pruritus, and patients with any pruritus scored significantly worse than those with no pruritus

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Furthermore, CD8 + T cells use IDO1 by the Kyn pathway to produce nicotinamide adenine dinucleotide (NAD), which is essential for metabolism and antitumor activity [117]

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