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Abbreviations PD: Parkinson's disease -syn: -synuclein SN: Substantial nigra PTMs: Post-translational modifications AKT: Protein kinase B mTORC1: Mechanistic target of rapamycin complex 1 TFEB: Transcription factor EB IGF2: Insulin-like growth factor 2 ZFP27: Transcription factor zinc finger protein 27 IRP: Iron regulatory protein IRE: Iron response element ROS: Reactive oxygen species HSPGs: Heparan sulfate proteoglycans CK2: Casein kinase 2 PLK2: Polo-like kinase 2 DMT1: Divalent metal-ion transporter 1 MAPK: Mitogen-activated protein kinase DFP: Deferiprone TfR: Transferrin receptor DMT1: Divalent metal transporter 1 FAC: Ferric ammonium citrate TEM: Transmission electron microscopy cryo-EM: Cryo-electron microscopy ThT: Thioflavin Glu: Glutamate Asp: Aspartate NMR: Nuclear magnetic resonance DFO: Deferoxamine RIPK1: Receptor-interacting protein kinase 1 RIPK3: Receptor-interacting protein kinase 3 MLKL: Mixed lineage kinase domain-like References Abeyawardhane DL, et al