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People carrying reduced-activity variants tend to clear food-derived histamine more slowly, which is why high-histamine meals aged cheese, cured meats, fermented foods, wine can trigger reactions

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14,49 In summary, the contributions of several risk factors to acute altitude sickness yield controversial results, and it is still unclear whether and how some determinants affect the occurrence and development of acute mountain illness, especially HACE and HAPE

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The advisory meeting is scheduled for 24 July 2026, so the proposal was not a final FDA determination when this article was reviewed