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A unifying model for mTORC1-mediated regulation of mRNA translation

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Proinflammatory cytokines such as IL-1, TNF-, and IL-6 can alter the expression of iron transporters and storage proteins, leading to increased cellular iron uptake and decreased iron export [214] through the upregulation of TfR1 and DMT1 expression and the downregulation of ferroportin expression [214,215]