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doi: 10.3390/ijms231911701 34 LiJ.MengL.RenS.JiaC.LiuR.JiangH.et al

046 Group 1 vs Group 4: P = 0

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SAM and SAH show pathway activity Low SAM and elevated SAH represent different biochemical barriers and should not automatically receive the same treatment

Pharmacological inhibition of GPX4 accelerates motor neuron degeneration and death (366, 367, 369), whereas GPX4 overexpression delays disease onset, improves motor function, and prolongs survival (368, 371)