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Chrysin (CN), a flavonoid extracted from Passiflora caerulea L., ameliorates hepatic lipid metabolic disorders by activating AMPK and modulating lipid metabolism-related proteins (e.g., SREBP1-c and ACC), while also suppressing the NLRP3/Caspase1 pathway to reduce pro-inflammatory cytokines (IL-1, IL-6, TNF-, IL-17), thereby counteracting NAFLD (Mishra et al., 2021

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Significant gaps exist in platform and regulation: head-to-head platform trials are absent, and the use of adaptive designs is only 3%

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