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Experimental results demonstrated that apelin-13, an endogenous ligand of the G protein-coupled receptor angiotensin II protein J (APJ), increased DRP1 expression, inhibited fusion-related protein expression, and stimulated VSMC mitophagy and abnormal proliferation, which exacerbated the development of atherosclerosis [227]

Boyd, A.W

KaplanAZelichaHYaskolka MeirARinottETsabanGLevakovGet alThe effect of a high-polyphenol mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the dietary intervention randomized controlled trial polyphenols unprocessed study (DIRECT PLUS)

Iron, copper, zinc, and manganese are cofactors for the antioxidant enzymes catalase and superoxide dismutase, as shown below

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