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10.3390/ijms21197152 242 LeeS.HwangN.SeokB

Under oxidative stress, CSF-cNs upregulated the activity of ATG4 by combining H 2 O 2 with the cysteine 81 sites of ATG4 and activated ATG4-promoted LC3 lipidation, which is essential for autophagy initiation, and promoted the formation of autophagosomes (Scherz-Shouval et al., 2007