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Of note, we performed this analysis in 3 independent human cell lines expressing mitotags that enable immunopurification of mitochondria and identification of mitochondrial metabolites whose abundance changes upon SLC25A39 loss 15

METTL17 knockdown sensitizes CRC cells to radiotherapy by impairing mitochondrial RNA methylation, which disrupts mitochondrial protein synthesis and exacerbates lipid peroxidation and ROS accumulation

This stacking approach lacks formal study but has theoretical basis

In light of the recently published research showing how 5 fruit and veg portions a day may actually not be enough to keep us healthy, it might be worth trying to follow the recommendations of 10-a-day

2015;64(Suppl 1):A1-A288.

Inflammatory cytokines, such as TNF, IFN-, and IL-6, impair HSC self-renewal and differentiation, leading to accelerated aging and depletion of the HSC pool