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La rduction de l'indice de mlanine tait statistiquement significative par rapport au placebo dans la majorit des essais, mais les auteurs ont conclu que les limites mthodologiques principalement la petite taille des cohortes et l'absence de donnes long terme ne permettaient pas de considrer l'effet claircissant comme bien tabli

Weight of evidence: Overall evidence is Moderate : pediatric trials show lipid-peroxidation reduction and improved antioxidant status, with mixed behavioral effects

210 Furthermore astrocytes are key elements for anti-oxidative defence being the main scavengers of reactive oxygen species