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More structural changes like meaningful reductions in wrinkle depth or improved skin laxity take longer, with most protocols requiring 10 to 16 weeks of consistent use before those changes are clearly visible

10.1002/j.1460-2075.1986.tb04528.x EMBO J

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Taken together, GH excess associated with poorly controlled T1DM induces podocyte injury, characterized by podocyte hypertrophy, apoptosis, dedifferentiation of podocytes (epithelialmesenchymal transition) and/or cross-linking of the basement membrane resulting in increased podocyte permeability to albumin and detachment of podocytes from the glomerular basement membrane (Fig

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