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Selective activation of Ca2+-dependent PKCs by thymeleatoxin induces cholestasis and retrieval of Bsep from the canalicular membrane in the isolated perfused rat liver.144 Interestingly, the canalicular ATP-binding cassette transporter, multidrug resistance protein 1 (Mdr1), the closest homologue of Bsep, is phosphorylated by PKC at 3 serine residues at the C-terminal, linker region, which binds to the actin-associated protein, HAX-1.145 Whether this phosphorylation occurs also for Bsep remains to be ascertained

Nolan (Stanford Univ., Stanford, CA) and transfected with vector containing ABCC1 using polyethyleneimine (PEI) (Boussif et al

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However, it emphasizes the need for more scientific evaluation to substantiate these claims

Supporting the cardiovascular system

doi:10.1093/carcin/23.4.599