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However, this previous study did not offer any explanation for the discrepancy

Zhong X, Tang T-T, Zhang Y, Xue D-D, Shen A-R, Li N, et al

A good example of this is given by flutamide, an antiandrogen used in the treatment of prostatic carcinoma, which undergoes substantial metabolism in vivo with hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline