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Dysregulated iron homeostasis amplifies ferroptotic susceptibility through Fenton chemistry-driven lipid peroxidation and polyamine synthesis via the ODC1-MYC axis, a metabolic and oxidative cascade prominently observed in the inflamed synovium of rheumatoid arthritis ( Inducing ferroptosis in specific cell populations using agents like Imidazole ketone erastin (IKE) can suppress synovial fibroblast proliferation and inflammation (104)

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Surprisingly, overexpression of either spliced XBP1 (XBP1s) or unspliced XBP1 (XBP1u) failed to re-sensitize IRE1-null MDA-MB-231 cells to ferroptosis induction (Fig

Conclusion: Long- term outcomes among HBV negative LT recipients receiving TAF monotherapy showed sustained prevention of de novo HBV infection from HBcAb+ donors alongside continued improvements in essential hepatic and renal safety indicators

NICE stands for National Institute of Health and Care Excellence