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Oxidative modifications of various proteins in many different sub-cellular organelles (e.g., mitochondria, ER, etc) would promote their inactivation, resulting in mitochondrial dysfunction and ER stress

Since regulation by anti-inflammatory molecules is impaired in some older adults, this chronic inflammation becomes harmful

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In Aspergillus awamori , the transcriptional regulation of gdhA is strongly influenced by nitrogen source availability, consistent with its involvement in extracellular protein secretion [59]

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Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation