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These immunogenic properties are particularly significant in glioblastoma, where ferroptosis-related gene signatures demonstrate strong predictive value for response to PD-1 blockade in recurrent tumors, suggesting an intrinsic synergy between ferroptosis and immune checkpoint inhibition [129]

Microenvironmental influences on T cell immunity in cancer and inflammation

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Gugan P

This has been explored by clinical trials, the most notable of which was METAOD005

Other studies have explored DSIPs impact on LH secretion and thyroid function, though its worth pointing out that these findings arent always consistent across the available literature