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Genomic sections displaying sequence conservation over time within a single viral species or evolutionary conservation between members of the coronavirus family despite high mutation rates are indicative of essential regions of the viral genome that are functionally constrained, such as the fusion peptide within the spike S2 region [68, 69]

While both conjugates showed cytotoxicity in isolated rat renal proximal tubular cells, cytotoxicity was reduced for OPMA but not for its S -oxide when the cells were treated with methimazole, an inhibitor of flavin-containing monooxygenase (FMO)

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Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury

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