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Compared with patients with normal nucleus pulposus, patients with lumbar disc herniation presented higher haemoglobin concentrations in the disc nucleus pulposus, a higher quantity of dark iron particles following staining, and elevated expression levels of HO-1 (177)

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in fact, it can also favor cancer development due to its potential negative impact on anticancer immunity (366)

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(68) highlighted in their review that pH-sensitive nanoparticles- commonly composed of materials such as alginate and chitosan- can modulate their size, solubility, and drug release rate in response to pH-dependent physicochemical changes