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Elucidating the mechanisms of Buyang Huanwu Decoction in treating chronic cerebral ischemia: a combined approach using network pharmacology, molecular docking, and in vivo validation

The interplay of transition metals in ferroptosis and pyroptosis

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This compound has an internal disulfide bond of 38 that is reduced in the presence of cellular glutathione to generate a sulfhydryl (thiol) moiety, which is the active form of Romidepsin behaving as a Zn 2+ binding group in the active site

10.1042/BCJ20170714 109 NaralaV