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The University of Michigan also warns that a B12 shot is not recommended for people with Lebers disease (7)

If you dont notice any improvement and you were not deficient to begin with, it could mean your vitamin levels were adequate and the injection is simply maintaining that status

too high signals overresponse and is a contraindication to continuing

Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism