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Although the previously targeted receptors (e.g., folate receptor, prostate specific membrane antigen, carbonic anhydrase IX, EGF receptor, etc.) all exhibit expression in a subset of healthy cells 23 , zan-DNP should have no healthy cell counterpart, perhaps accounting for its virus-infected cell specificity

As we age, the number of regulatory CD4 + CD25 + T cells, which help prevent autoimmune events, decreases, thus reducing the number of them may be beneficial to the development of autoimmune process (122)

The general dysbiosis of microbial metabolites, beyond just BAs, has also been noted as a potential hallmark in colorectal cancer development (186)

doi:10.1074/jbc.M109.067017, PMID: 20498365 Tavazzi B, Amorini AM, Fazzina G, Di Pierro D, Tuttobene M, Giardina B, Lazzarino G (2001) Oxidative stress induces impairment of human erythrocyte energy metabolism through the oxygen radical-mediated direct activation of AMP-deaminase

A meta-analysis including 11 prospective studies (754,729 participants, 58,297 incident type 2 diabetes cases) found a 13% lower risk of type 2 diabetes with high cruciferous vegetable intake ( trend : 50 mmol/mol) (Thorup et al., 2021)