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LDH upregulation drives lactate accumulation and accelerates glycolysis [123], while MCT upregulation mediates acid efflux [124], shaping the TME

Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., 2012)

Soluble phospho-tau from Alzheimers disease hippocampus drives microglial degeneration

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Hepatocytes are polygonal cells with a central nucleus arranged in radial rows separated by hepatic sinusoids lined with endothelial cells and Kupffer cells