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Failure of these intuitive drug therapies underlie the complicated nature of FRDA etiology

The ferroptosis pathway involves several critical mechanisms: iron uptake via transferrin receptor, ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4), iron export through ferroportin regulated by hepcidin, accumulation of lipid peroxides via the Fenton reaction, and antioxidant defense via glutathione peroxidase 4 (GPx4) and glutathione (GSH)

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and (iii) eNOS-mediated arginine catabolism leading to upregulation of wingless/integrated (Wnt) pathway and accelerated progression of colorectal cancer [92]

When additional pathogens enter the picture and reactivate EBV, this autoimmune process can be initiated or intensified

The effect of exercise on GABA signaling pathway in the model of chemically induced seizures