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After consideration of public comments, we are finalizing the proposed prepaid shared savings application procedures under 425.640(c) with modifications to allow ACOs that renewed to enter an agreement period beginning on January 1, 2025, the option to elect to participate in prepaid shared savings starting with performance year 2026 without renewing again (as described and for the reasons explained elsewhere in section III.G.5

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Conversely, the action of enzymes blocking prostaglandin biosynthesis, such as aspirin-acetylated COX-2 and S-nitrosylated COX-2, leads to the generation of 15-hydroperoxy-eicosatetraenoic acid (15-HpETE) [111]