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Additionally, 1,25-(OH) 2 D 3 blocks nuclear factor B activation and binding to nuclear factor B consensus sequences, downregulates IL-8 and IL-12 cytokine secretion, weakens DC antigen presentation and immune response activation functions, and reduces T cell numbers and activity in thyroid tissue ( Although existing evidence suggests that 1,25-(OH) 2 D 3 , as an immunomodulator, multi-pathway inhibits reactive T lymphocytes from attacking self-antigens, suppresses abnormal immune responses, reduces pro-inflammatory factor production, regulates apoptosis to protect thyroid tissue, and supports the potential value of vitamin D in the prevention and treatment of AITD, further research is needed to address the following key issues: (1) Determining the optimal dose and timing of vitamin D supplementation therapy

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J Allergy Clin Immunol 150(6):13331393