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This material is based upon work supported by PHS NRSA T32GM007270 from NIGMS (to HT and AJP), National Science Foundation Graduate Research Fellowship Program under grant no

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In pulmonary artery smooth muscle cells and a pulmonary arterial hypertension rat model, hypoxia (3% O 2 for cells and 10% O 2 for mice, respectively) induces the deubiquitinase OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1), to stabilize SLC7A11, and eventually inhibiting erastin-induced ferroptosis [115]

Samples were analyzed using a Gallios multi-color flow cytometer instrument (Beckman Coulter, Brea, CA, USA) set up with the 3 lasers 10 colors standard configuration

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Epigenetic recoding of the immune microenvironment has recently garnered increasing research interest