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There is no recommended dose for patients whose creatinine clearance is less than 45 mL/min [see Use in Specific Populations (8.6)]

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At the start and end of the first cycle, clinical investigations of serum Hcy, serum B12, serum FA, PT, aPTT, fibrinogen, transferrin (Tf), transthyretin (TTR, pre-albumin), retinol-binding protein (RBP), complete blood cell count, and blood chemistry were performed