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Jabir NR, Rehman MT, AlAjmi MF, Ahmed BA, Tabrez S (2023) Prioritization of bioactive compounds envisaging yohimbine as a multi targeted anticancer agent: insight from molecular docking and molecular dynamics simulation

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Vitexin can not only suppress de novo lipogenesis but also enhance fatty acid oxidation and lipolysis, in addition, it can improve insulin signaling in HFD mice possibly through binding to leptin receptor and activating AMPK [33, 34]

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The fact that the inhibitor of gamma-glutamylcysteine synthetase did not alter the response of glutathione is of importance, since it demonstrates that the increase of intracellular concentration of glutathione is not required to reduce the cell index