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As epigenetic marks, histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination, can be inherited and are essential for recruiting or activating downstream effectors (Liu and Si, 2024)

Regarding the prenatal period, a significant RCT involving pregnant women positive for anti-thyroid peroxidase antibody (TPOAb), demonstrated that selenium supplementation led to a notable reduction in TPOAb levels during and after pregnancy [20,33]