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Improved long-term outcome with chemoradiotherapy strategies in esophageal cancer

References Bhattacharya, D

Blood 138 , 11821193 (2021)

doi: 10.1021/acs.jafc.2c01712

For example, gemcitabine thermosensitive hydrogels or microspheres are used for intraperitoneal perfusion to treat peritoneal metastasis, which can form a drug sustained release reservoir in the peritoneal cavity, prolong local exposure time and reduce systemic toxicity (Xu et al., 2016)

This triggers a cascade of effects: accelerated keratinocyte proliferation, increased desquamation (shedding of the outer layer), and stimulation of collagen synthesis in the dermis