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The pathogenesis of polycystic ovary syndrome (pcos): the hypothesis of pcos as functional ovarian hyperandrogenism revisited

Nature 438 (7064): 9093

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doi: 10.1016/j.ccr.2023.215481 132 DiercksCSYaghiOM

This issue is especially important for therapies directed at mitochondriaorganelle crosstalk, because the balance between reversible stress adaptation and irreversible bioenergetic collapse is strongly time-dependent, and the therapeutic window in patients is often substantially later than in experimental studies

Tobacco Smoke: Cigarette smoke contains 4,000 different chemicals that cause extensive free-radical damage, requiring glutathione for neutralisation