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ROS-induced damage to DNA, proteins, and lipids can directly lead to cell death, but it also promotes microglial activation and the release of pro-inflammatory cytokines, further exacerbating neurodegeneration (Tfilin et al., 2023)

390 (3): p

Biochemistry 53 , 58345847 (2014)

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

In cardiovascular diseases, antioxidants can help reduce oxidative stress and improve endothelial function, thus potentially preventing atherosclerosis and other heart-related issues [198]