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Most patients with DOA plus carry missense variants affecting the GTPase domain rather than truncating mutations of OPA1, suggesting that a dominant negative effect might play a role in the pathogenesis of the plus phenotype [91,92,93]

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Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging

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37 Similarly, breath-actuated jet nebulizers, like the AeroEclipse II BAN (Monaghan Medical Corporation, Plattsburgh, NY), also deliver aerosol only on inspiration and tend to decrease drug wastage during aerosol therapy

Dysregulated NF-B has also been reported in other studies using RNA-seq and network analysis, where activation has been reported (Miller et al., 2016